2015 Division 2 Week 12 (Nov. 21 – Playoffs Round 1)
Week 12 of the 2015 Division 2 football season will take place solely on Saturday, November 21. Week 12 will start the Division 2 Playoffs featuring 24 of the 28 teams playing in the first round. All games are listed below.
| Date | Time (EST) | Road Team | Road Score | Home Team | Home Score | Notes |
| 11/21/2015 | 12:00 PM | Indiana (PA) | 47 | Charleston (WV) | 21 | Shepherd Region |
| 11/21/2015 | 12:00 PM | Virginia Union | 21 | Slippery Rock | 40 | Shepherd Region |
| 11/21/2015 | 12:00 PM | Bowie State | 29 | Assumption | 51 | Shepherd Region |
| 11/21/2015 | 12:00 PM | Texas A&M-Commerce | 30 | Ferris State | 48 | Midwestern State Region |
| 11/21/2015 | 12:00 PM | Grand Valley State | 45 | Ashland | 28 | Midwestern State Region |
| 11/21/2015 | 12:00 PM | Carson-Newman | 59 | Valdosta State | 61 | West Georgia Region |
| 11/21/2015 | 12:00 PM | Tuskegee | 26 | Catawba | 16 | West Georgia Region |
| 11/21/2015 | 1:00 PM | Newberry | 7 | North Alabama | 50 | West Georgia Region |
| 11/21/2015 | 1:00 PM | Emporia State | 51 | Minnesota State-Mankato | 49 | Northwest Missouri State Region |
| 11/21/2015 | 1:00 PM | Sioux Falls | 16 | Henderson State | 23 | Northwest Missouri State Region |
| 11/21/2015 | 1:00 PM | Kentucky Wesleyan | 27 | East Tennessee State | 42 | |
| 11/21/2015 | 2:00 PM | Indianapolis | 14 | Colorado State-Pueblo | 27 | Midwestern State Region |
| 11/21/2015 | 4:00 PM | Augustana (SD) | 31 | Humboldt State | 45 | Northwest Missouri State Region |
| 11/21/2015 | 7:00 PM | Miles | 7 | Alabama State | 26 |